NFL Odds - Live NFL Betting Lines. September 02, - Compare and find the best NFL spreads and lines anywhere on the internet!. NFL odds Preseason Week 1 betting lines and trends roundup the first game of Week 1 of the NFL preseason schedule, with Houston among the underdogs at the sportsbooks. Michael Shroyer-USA TODAY Sports. NFL odds NFL preseason Week 3 betting lines, trends roundup Bill Streicher-USA TODAY Sports Friday night also has two games on the schedule as the New England Patriots (-2) visit the Detroit Lions and the.